Repository Universitas Pakuan

Detail Karya Ilmiah Dosen

**Leny Heliawati1,*, Seftiana Lestari1 , Uswatun Hasanah1 , Dwipa Ajiati2 , Dikdik Kurnia**

Judul : Phytochemical Profile of Antibacterial Agents from Red Betel Leaf (Piper crocatum Ruiz and Pav) against Bacteria in Dental Caries

Abstrak :
Based on data from The Global Burden of Disease Study in 2016, dental and oral health problems, especially dental caries, are a disease experienced by almost half of the world’s population (3.58 billion people). One of the main causes of dental caries is the pathogenesis of Streptococcus mutans. Prevention can be achieved by controlling S. mutans using an antibacterial agent. The most commonly used antibacterial for the treatment of dental caries is chlorhexidine. However, long-term use of chlorhexidine has been reported to cause resistance and some side effects. Therefore, the discovery of a natural antibacterial agent is an urgent need. A natural antibacterial agent that can be used are herbal medicines derived from medicinal plants. Piper crocatum Ruiz and Pav has the potential to be used as a natural antibacterial agent for treating dental and oral health problems. Several studies reported that the leaves of P. crocatum Ruiz and Pav contain secondary metabolites such as essential oils, flavonoids, alkaloids, terpenoids, tannins, and phenolic compounds that are active against S. mutans. This review summarizes some information about P. crocatum Ruiz and Pav, various isolation methods, bioactivity, S. mutans bacteria that cause dental caries, biofilm formation mechanism, antibacterial properties, and the antibacterial mechanism of secondary metabolites in P. crocatum Ruiz and Pav

Tahun : 2022 Media Publikasi : Jurnal Internasional

Kategori : Jurnal No/Vol/Tahun : 2861 / 27 / 2022

ISSN/ISBN : -

PTN/S : universitas pakuan Program Studi : PENDIDIKAN ILMU PENGETAHUAN ALAM

Bibliography :
Kuang, X.; Chen, V.; Xu, X. Novel Approaches to the Control of Oral Microbial Biofilms. Biomed. Res. Int. 2018, 2018, 6498932. [CrossRef] [PubMed] 2. Jiao, Y.; Tay, F.R.; Niu, L.-N.; Chen, J. Hua Advancing Antimicrobial Strategies for Managing Oral Biofilm Infections. Int. J. Oral Sci. 2019, 11, 28. [CrossRef] [PubMed] 3. Verma, D.; Garg, P.K.; Dubey, A.K. Insights into the Human Oral Microbiome. Arch. Microbiol. 2018, 200, 525–540. [CrossRef] 4. Peres, M.A.; Macpherson, L.M.D.; Weyant, R.J.; Daly, B.; Venturelli, R.; Mathur, M.R.; Listl, S.; Celeste, R.K.; Guarnizo-Herreño, C.C.; Kearns, C.; et al. Oral Diseases: A Global Public Health Challenge. Lancet 2019, 394, 249–260. [CrossRef] 5. Irani, S. Oral Health and Related Factors: An Update. J. Int. Oral Health 2016, 8, 1140–1144. [CrossRef] 6. Huang, R.; Li, M.; Gregory, R.L. Bacterial Interactions in Dental Biofilm. Virulence 2011, 2, 435–444. [CrossRef] 7. Kolenbrander, P.E. Multispecies Communities: Interspecies Interactions Influence Growth on Saliva as Sole Nutritional Source. Int. J. Oral Sci. 2011, 3, 49–54. [CrossRef] 8. Huang, R.; Li, M.; Gregory, R.L. Effect of Nicotine on Growth and Metabolism of Streptococcus mutans. Eur. J. Oral Sci. 2012, 120, 319–325. [CrossRef] 9. Kassebaum, N.J.; Bernabé, E.; Dahiya, M.; Bhandari, B.; Murray, C.J.L.; Marcenes, W. Global Burden of Untreated Caries: A Systematic Review and Metaregression. J. Dent. Res. 2015, 94, 650–658. [CrossRef] 10. Saquib, S.A.; Alqahtani, N.A.; Ahmad, I.; Kader, M.A.; Al Shahrani, S.S.; Asiri, E.A. Evaluation and Comparison of Antibacterial Efficacy of Herbal Extracts in Combination with Antibiotics on Periodontal Pathobionts: An In Vitro Microbiological Study. Antibiotics 2019, 8, 89. [CrossRef] 11. Suri, M.A.; Azizah, Z.; Asra, R. A Review: Traditional Use, Phytochemical and Pharmacological Review of Red Betel Leaves (Piper crocatum Ruiz & Amp; Pav). Asian J. Pharm. Res. Dev. 2021, 9, 159–163. [CrossRef] 12. Gurning, K.; Lumbangaol, S.; Situmorang, R.F.R.; Silaban, S. Determination of Phenolic Contents and Antioxidant Activity Test of Ethanol Extract of Sirih Merah (Piper crocatum Ruiz & Pav.) Leaves Using the DPPH Method. J. Pendidik. Kim. 2021, 13, 137–142. [CrossRef] 13. Rizkita, A.D.; Cahyono, E.; Mursiti, S. Isolasi dan Uji Antibakteri Minyak Daun Sirih Hijau dan Merah Terhadap Streptococcus mutans. J. Chem. Sci. 2017, 6, 279–286. 14. Larsen, T.; Fiehn, N. Dental Biofilm Infections—An Update. APMIS 2017, 125, 376–384. [CrossRef] 15. Amin, M.; Ain, N.; Mohd, A.; Sharaf, A.; Al-Hammadi, S. Materials Science & Engineering C Organic and Inorganic Antibacterial Approaches In Combating Bacterial Infection for Biomedical Application. Mater. Sci. Eng. C 2021, 118, 111382. [CrossRef] 16. Cui, T.; Luo, W.; Xu, L.; Yang, B.; Zhao, W.; Cang, H. Progress of Antimicrobial Discovery Against The Major Cariogenic Pathogen Streptococcus mutans. Curr. Issues Mol. Biol. 2019, 32, 601–644. [CrossRef] 17. Erviana, R. Active Compounds Isolated from Red Betel (Piper crocatum Ruiz & Pav) Leaves Active Against Streptococcus mutans through Its Inhibition Effect on Glucosyltransferase Activity. J. Med. Sci. 2011, 43, 71–78. 18. Vaillancourt, K.; Lebel, G.; Pellerin, G.; Lagha, A.B.; Grenier, D. Effects of the Licorice Isoflavans Licoricidin and Glabridin on the Growth, Adherence Properties, and Acid Production of Streptococcus mutans, and Assessment of Their Biocompatibility. Antibiotics 2021, 10, 163. [CrossRef] 19. Avilés-Reyes, A.; Miller, J.H.; Simpson-Haidaris, P.J.; Lemos, J.A.; Abranches, J. Cnm Is A Major Virulence Factor of Invasive Streptococcus mutans and Part of A Conserved Three-Gene Locus. Mol. Oral Microbiol. 2014, 29, 11–23. [CrossRef] 20. Takahashi, N.; Nyvad, B. The Role of Bacteria in the Caries Process: Ecological Perspectives. J. Dent. Res. 2011, 90, 294–303. [CrossRef] 21. Xiao, J.; Klein, M.I.; Falsetta, M.L.; Lu, B.; Delahunty, C.M.; Yates, J.R.; Heydorn, A.; Koo, H. The Exopolysaccharide Matrix Modulates The Interaction between 3D Architecture and Virulence of A Mixed-Species Oral Biofilm. PLoS Pathog. 2012, 8, 7–9. [CrossRef] [PubMed]

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Detail Karya Ilmiah Dosen

**Leny Heliawati1,*, Seftiana Lestari1 , Uswatun Hasanah1 , Dwipa Ajiati2 , Dikdik Kurnia**

Judul	:	Phytochemical Profile of Antibacterial Agents from Red Betel Leaf (Piper crocatum Ruiz and Pav) against Bacteria in Dental Caries
Abstrak	:	Based on data from The Global Burden of Disease Study in 2016, dental and oral health problems, especially dental caries, are a disease experienced by almost half of the world’s population (3.58 billion people). One of the main causes of dental caries is the pathogenesis of Streptococcus mutans. Prevention can be achieved by controlling S. mutans using an antibacterial agent. The most commonly used antibacterial for the treatment of dental caries is chlorhexidine. However, long-term use of chlorhexidine has been reported to cause resistance and some side effects. Therefore, the discovery of a natural antibacterial agent is an urgent need. A natural antibacterial agent that can be used are herbal medicines derived from medicinal plants. Piper crocatum Ruiz and Pav has the potential to be used as a natural antibacterial agent for treating dental and oral health problems. Several studies reported that the leaves of P. crocatum Ruiz and Pav contain secondary metabolites such as essential oils, flavonoids, alkaloids, terpenoids, tannins, and phenolic compounds that are active against S. mutans. This review summarizes some information about P. crocatum Ruiz and Pav, various isolation methods, bioactivity, S. mutans bacteria that cause dental caries, biofilm formation mechanism, antibacterial properties, and the antibacterial mechanism of secondary metabolites in P. crocatum Ruiz and Pav
Tahun	:	2022	Media Publikasi	:	Jurnal Internasional
Kategori	:	Jurnal	No/Vol/Tahun	:	2861 / 27 / 2022
ISSN/ISBN	:	-
PTN/S	:	universitas pakuan	Program Studi	:	PENDIDIKAN ILMU PENGETAHUAN ALAM
Bibliography	:	Kuang, X.; Chen, V.; Xu, X. Novel Approaches to the Control of Oral Microbial Biofilms. Biomed. Res. Int. 2018, 2018, 6498932. [CrossRef] [PubMed] 2. Jiao, Y.; Tay, F.R.; Niu, L.-N.; Chen, J. Hua Advancing Antimicrobial Strategies for Managing Oral Biofilm Infections. Int. J. Oral Sci. 2019, 11, 28. [CrossRef] [PubMed] 3. Verma, D.; Garg, P.K.; Dubey, A.K. Insights into the Human Oral Microbiome. Arch. Microbiol. 2018, 200, 525–540. [CrossRef] 4. Peres, M.A.; Macpherson, L.M.D.; Weyant, R.J.; Daly, B.; Venturelli, R.; Mathur, M.R.; Listl, S.; Celeste, R.K.; Guarnizo-Herreño, C.C.; Kearns, C.; et al. Oral Diseases: A Global Public Health Challenge. Lancet 2019, 394, 249–260. [CrossRef] 5. Irani, S. Oral Health and Related Factors: An Update. J. Int. Oral Health 2016, 8, 1140–1144. [CrossRef] 6. Huang, R.; Li, M.; Gregory, R.L. Bacterial Interactions in Dental Biofilm. Virulence 2011, 2, 435–444. [CrossRef] 7. Kolenbrander, P.E. Multispecies Communities: Interspecies Interactions Influence Growth on Saliva as Sole Nutritional Source. Int. J. Oral Sci. 2011, 3, 49–54. [CrossRef] 8. Huang, R.; Li, M.; Gregory, R.L. Effect of Nicotine on Growth and Metabolism of Streptococcus mutans. Eur. J. Oral Sci. 2012, 120, 319–325. [CrossRef] 9. Kassebaum, N.J.; Bernabé, E.; Dahiya, M.; Bhandari, B.; Murray, C.J.L.; Marcenes, W. Global Burden of Untreated Caries: A Systematic Review and Metaregression. J. Dent. Res. 2015, 94, 650–658. [CrossRef] 10. Saquib, S.A.; Alqahtani, N.A.; Ahmad, I.; Kader, M.A.; Al Shahrani, S.S.; Asiri, E.A. Evaluation and Comparison of Antibacterial Efficacy of Herbal Extracts in Combination with Antibiotics on Periodontal Pathobionts: An In Vitro Microbiological Study. Antibiotics 2019, 8, 89. [CrossRef] 11. Suri, M.A.; Azizah, Z.; Asra, R. A Review: Traditional Use, Phytochemical and Pharmacological Review of Red Betel Leaves (Piper crocatum Ruiz & Amp; Pav). Asian J. Pharm. Res. Dev. 2021, 9, 159–163. [CrossRef] 12. Gurning, K.; Lumbangaol, S.; Situmorang, R.F.R.; Silaban, S. Determination of Phenolic Contents and Antioxidant Activity Test of Ethanol Extract of Sirih Merah (Piper crocatum Ruiz & Pav.) Leaves Using the DPPH Method. J. Pendidik. Kim. 2021, 13, 137–142. [CrossRef] 13. Rizkita, A.D.; Cahyono, E.; Mursiti, S. Isolasi dan Uji Antibakteri Minyak Daun Sirih Hijau dan Merah Terhadap Streptococcus mutans. J. Chem. Sci. 2017, 6, 279–286. 14. Larsen, T.; Fiehn, N. Dental Biofilm Infections—An Update. APMIS 2017, 125, 376–384. [CrossRef] 15. Amin, M.; Ain, N.; Mohd, A.; Sharaf, A.; Al-Hammadi, S. Materials Science & Engineering C Organic and Inorganic Antibacterial Approaches In Combating Bacterial Infection for Biomedical Application. Mater. Sci. Eng. C 2021, 118, 111382. [CrossRef] 16. Cui, T.; Luo, W.; Xu, L.; Yang, B.; Zhao, W.; Cang, H. Progress of Antimicrobial Discovery Against The Major Cariogenic Pathogen Streptococcus mutans. Curr. Issues Mol. Biol. 2019, 32, 601–644. [CrossRef] 17. Erviana, R. Active Compounds Isolated from Red Betel (Piper crocatum Ruiz & Pav) Leaves Active Against Streptococcus mutans through Its Inhibition Effect on Glucosyltransferase Activity. J. Med. Sci. 2011, 43, 71–78. 18. Vaillancourt, K.; Lebel, G.; Pellerin, G.; Lagha, A.B.; Grenier, D. Effects of the Licorice Isoflavans Licoricidin and Glabridin on the Growth, Adherence Properties, and Acid Production of Streptococcus mutans, and Assessment of Their Biocompatibility. Antibiotics 2021, 10, 163. [CrossRef] 19. Avilés-Reyes, A.; Miller, J.H.; Simpson-Haidaris, P.J.; Lemos, J.A.; Abranches, J. Cnm Is A Major Virulence Factor of Invasive Streptococcus mutans and Part of A Conserved Three-Gene Locus. Mol. Oral Microbiol. 2014, 29, 11–23. [CrossRef] 20. Takahashi, N.; Nyvad, B. The Role of Bacteria in the Caries Process: Ecological Perspectives. J. Dent. Res. 2011, 90, 294–303. [CrossRef] 21. Xiao, J.; Klein, M.I.; Falsetta, M.L.; Lu, B.; Delahunty, C.M.; Yates, J.R.; Heydorn, A.; Koo, H. The Exopolysaccharide Matrix Modulates The Interaction between 3D Architecture and Virulence of A Mixed-Species Oral Biofilm. PLoS Pathog. 2012, 8, 7–9. [CrossRef] [PubMed]
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