Repository Universitas Pakuan

Detail Karya Ilmiah Dosen

Oom Komala, Dwi Wahyu Widayat, Muztabadihardja

Judul : Bioactive Compounds and Antibacterial Activity of Ethanolic Extracts of Curcuma mangga Val Against Staphylococcus aureus
Abstrak :

Temu mangga (Curcuma mangga) is a powerful medicinal plants as antioxidants because it contains curcuminoids. The constituents of bioactive chemical and antibacterial activity from temu mangga had not been widely researched and other scientific information is still limited. This study aimed  to examine  the antibacterial activity of the plants Curcuma mangga for pathogenic bacteria Staphylococcus aureus and describes the phytochemical analysis.  Antibacterial  research conducted by the diffusion method of ethanol extracts against  pathogenic bacteria, and qualitatively tested for the presence of chemical constituents. The results showed antibacterial activity against Staphylococcus aureus.  The diameter of  the largest barriers to S. aureus (30.5 mm) in 8% of ethanol extracts similar to  Amoxicillin  30 μg/ml. Minimum Inhibitory Concentration  was 2% of ethanolic extracts. Phytochemical analysis  of the results of the ethanol extract of Curcuma mangga showed varying  bioactive compounds consisting  of flavonoids, saponins, quinones  and steroids were the most prominent. The research results prove that the C. mangga is a good  source of antibacterial against S. aureus.

Tahun : 2016 Media Publikasi : Jurnal Internasional
Kategori : Jurnal No/Vol/Tahun : 6 / 2 / 2016
ISSN/ISBN : 2395-3470
PTN/S : Universitas Pakuan Program Studi : BIOLOGI
Bibliography :

[1] Abas, F., Lajis, N.H., Shaari, K., Israf, D.A., Stanslas, J., Yusuf, U.K. & Raoft, S.M., Alabdane diterpene glucoside from the rhizome of Curcuma mangga, Journal of Natural Products, 68, pp.1090-1093, 2005. [2] Akinjogunla, O.J., Yah, C.S., Eghafona, N.O. & Ogbemudia, F.O., Antibacterial activity of leave extracts of Nymphaea lotus ( Nymphaeaceae) on Methicillin resistant Staphylococcus aureus (MRSA) and Vancomycin resistant Staphylococcus aureus (VRSA) isolated from clinical samples, Annuals of Biological Research, 1(2), pp. 174-184, 2010. [3] Elizabeth, K.M., Antimicrobial activity of Terminalia bellerica Indian, J.Clin. Biochem, 20, pp.150-153, 2005. [4] Galeotti, F., Barile, E., Curir, P., Dolci, M.& Lanzotti, V., Flavonoids from carnation (Dianthus caryophyllus) and their antifungal activity, Phytochemistry Letters, I, pp.44, 2008. [5] Harbone, J.B.,  Phytochemical Method : As Guide to Modern Techniques of Plant Analysis, 3 rd edition, Chapman and Hall, London, pp 302, 1998. [6] Jonathan, G.C., Robert, A.B., Steven, G.W. & Noel, L.O., Natural Occuring  fish Poisons from Plants, J.Chem. Educ., 81(10), pp.1457, 2004. [7] Palombo, E.A. & Semple, S.J., Antibacterial activity of traditional medicinal plants. J Ethnopharmacol, 77, pp.151-157, 2001. [8] Parekh, J. & Chandren, S., In vitro antimicrobial activities of extracts of Launaea procumbens Roxb (Labiateae). Afr. J. Biomed. Res., 9, pp 89-93.2006. [9] Renisheya, J.J.M.T., Johnson, M., Mary, U.M. & Arthy, A., Antibacterial activity of ethanolic extracts of selected medicinal plants against human pathogens, Asian Pacific Journal of Tropical Biomedicine, pp.S76-S78, 2011. [10] Skene, C.D. & Philip, S., Saponin-adjuvanted particulate vaccines for Clinical Use, Methods, 40(1), pp. 53-59, 2006. [11] Sri Nurestri, A.M., Guan, S.L., Sok, L.H., Hashim, Y., Norhanom, A.W., Jean-Frederic, F.W. & Syed, A.A.S., Phytochemical and Cytotoxic Investigations of Curcuma mangga Rhizomes, Molecules, 16(6), pp.4539-4548, 2011. [12] Xu, R., Zhao, W., Xu, J., Shao, B. & Qin, G., Studies on bioactive saponins from Chinese medicinal plans, Advances in Experimental Medicine and Biology, 404 (3), pp 71-82, 1996. [13] Zamora-Ros,  R., Agudo, A., Lujan-Barroso, L., Romieu, I., Ferrari, P. & Knaze V, Dietary flavonoid and lignan intake and gastric adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, American  Journal  Of Clinical   Nutrition, , 96(6), pp. 1398-1408, 2012