Repository Universitas Pakuan

Detail Karya Ilmiah Dosen

Leny Heliawati, Yana Maolana Syah, Miranti Banyuning Bumi

Judul : Bryononic Acid: Antibacterial Compound from Fruit Hulls of S. koetjape Merr Extract
Abstrak :

Triterpenoid Bryononic Acid was isolated from Sandoricum koetjape Merr plant collected from Serang district, West Java, Indonesia, in which its chemical structures were elucidated by spectroscopic analysis. The antibacterial activity was carried out using a microdilution method. The antibacterial evaluation of extracts and fractions from the Sandoricum koetjape hulls was active against Salmonella enterica with their Minimum Inhibitory Concentrations (MIC) value of 6.0. μg/mL. The results showed that the extracted plant indicated antibacterial activity with strong spectrum. Thus, identifying the chemical constituents responsible for this antibacterial activity may lead to this discovery and production of new antibacterial drugs against microbes.

Tahun : 2019 Media Publikasi : Jurnal Internasional
Kategori : Jurnal No/Vol/Tahun : 1 / 12 / 2019
ISSN/ISBN : 0974-2115
PTN/S : Universitas Pakuan Program Studi : KIMIA
Bibliography :

Aisha AFA, Alrokayan SA, Abu-Salah KM, In Vitro Cytotoxic and Apoptotic Properties of the Stem Bark Extract of S.koetjape on Breast cancer cell, International Journal of Cancer Research, 5 (3), 2009, 123-129.
Aisha AFA, Sahib HB, Abu-Salah KM, Darwis Y, Abdul MAMS, Cytotoxic and Anti-Angiogenic Properties of the Stem Bark Extract of Sandoricum koetjape, International Journal of Cancer Research, 5 (3), 2009, 105-114.
Arias CA, Murray BE, A New Antibiotic and Evolution of Resistance, The New England Journal of Medicine, 372 (12), 2015, 1168-1170.
Fang X, Di YT, Hao XJ, The Advances in the Limonoid Chemistry of the Meliaceae Family, Current Organic Chemistry, 15 (9), 2011.

Heyne K, Tumbuhan Berguna Indonesia, Vol. II. Indonesia, Balai Penelitian dan Pengembangan Kehutanan, 1987, 1432.
Kongtun S, Jiratchariyakul W, Kummalue T, Tan-ariya P, Kunnachak S, Frahm AW, Cytotoxic properties of root extract and fruit juice of Trichosanthes, 2009.
Kosela S, Yulizar Y, Chairul, Tori M, Asakawa Y, Secomultiflorane-Type Triterpenoid Acids from Stem Bark of Sandoricum koetjape. Phytochemistry, 38 (3), 1995, 691-694.
Mahady GB, Medicinal plants for the prevention and treatment of bacterial infections, Current Pharmacology, 11 (19), 2015, 2405-2427.
Roy A, Saraf S, Limonoids: Overview of Significant Bioactive Triterpenes Distributed in Plants Kingdom, Biological & Pharmaceutical Bulletin, 29 (2), 2006, 191-201.
Sim KY, Lee HT, Triterpenoid and other Constituents from Sandoricum indicum, Phytochemistry, 11, 1972, 3341-3343.
Tan QG, Luo XD, Meliaceous Limonoids, Chemistry and Biological Activities, Chemical Reviews, 111, 2011, 7437-7522.
Tukiran, Saidah, Suyatno N, Hidayati, K Shimizu, Briononic Acid From The Hexane Extract Of Sandoricum koetjape Merr Stem Bark (Meliaceae), Indo. J. Chem, 6 (3), 2006, 304-306.