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Detail Karya Ilmiah Dosen

Tri Saptari Haryani, Triastinurmiatiningsih, Moerfiah, Fitra Akbar Nugraha

Judul : THE TEST OF Padina australis-BASED TABLET AS AN ANTI-DIARRHEAL MEDICINE ON Escherichia coli INDUCED MALE SPRAGUE DAWLEY RATS
Abstrak :

Diarrhea is a process of discharging feces from the body (defecation) in which the feces is half liquid or liquid-shaped and more watery than normal. One of its cause is the Escherichia coli bacteria. Diarrhea is often treated using chemical medicine like Loperamid, but because of its many side effects, people start using herbal medicine instead. Padina australis is a species of seaweed that can be used as a medicine, specifically to reduce the growth of Escherichia coli, which is a diarrhea-caused bacterium. This research aims to determine the effect of Padina australis-based tablet and its optimal dosage as an anti-diarrheal medicine. This research use tablets made from Padina australis extract and 30 male Sprague Dawley rat with age 2-3 months and weight ± 250 gr as the test subject. The method used in this research includes environmental adaptation on the test subject, producing Padina australis extract tablet suspension, testing tablet suspension on various concentrations, macroscopic and microscopic examination of test subject’s intestines using intestinal transit method, and histopathology examination of test subject’s organ. The result indicates that 3.78 mg/200 gr weights is the most optimal dosage to restore the condition of test subject’s intestine. Microscopic examination shows no tissue damage on the test subject’s digestive organs. Therefore, we conclude that Padina australis extract tablet has an anti-diarrheal effect on male Sprague Dawley rat with 3.78 mg/200 gr weights as the most optimal dosage.

Keyword: anti-diarrhea, male rat digestive organs, Padina australis extract tablet.

Tahun : 2018 Media Publikasi : Seminar Internasional
Kategori : Jurnal No/Vol/Tahun : - / - / -
ISSN/ISBN : -
PTN/S : Universitas Pakuan Program Studi : BIOLOGI
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