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Detail Karya Ilmiah Dosen

OOM KOMALA, TRIASTINURMIATININGSIH, RINA YULIANTI

Judul : ANTIFUNGAL ACTIVITY SARGASSUM CRASSIFOLIUM AND SARGASSUM POLYCYCTUM AGAINST CANDIDA ALBICANS
Abstrak :

Introduction: Sargassum crassifolium and Sargassum polycystum are brown algae species and contain active compounds such as flavonoids, alkaloids, saponins, phenols, and triterpenoids that act as antibacterial, antiviral and antifungal. Aims of study was to determine antifungal Sargassum crassifolium and Sargassum polycystum against Candida albicans. Methods: Antifungal activity of Sargassum crassifolium and Sargassum polycystum extract were examined using the disc diffusion methods with concentrations of 250 mg/ml and 500 mg/ml compared to Ketoconazole 50 µg/ml against Candida albicans through measurement of the width of the inhibition zone.    Qualitative phytochemical tests to know compound of alkaloids, triterpenoid, saponin, flavonoid, and tannin. Results: 500 mg/ml Sargassum crassifolium and Sargassum polycystum exhibited promising fungistatic agent against Candida albicans with diameter of inhibition zone i.e 22 mm for Sargassum crassifolium and 21.6 mm Sargassum polycystum and the its  power of the antifungal  is lower than Ketoconazole 50 µg/ml.  Sargassum crassifolium and Sargassum polycystum contained triterpenoids, saponins, and flavonoids. Conclusion: 96% ethanol  extract  of Sargassum crassifolium and Sargassum polycystum have antifungal activity of  Candida albicans. Antifungal effect Sargassum crassifolium (22 mm) not real different with  Sargassum polycystum (21.6 mm) against Candida albicans.

Tahun : 2018 Media Publikasi : Seminar Internasional
Kategori : Poster No/Vol/Tahun : 1 / 3 / 2018
ISSN/ISBN : 274/SK-SKP/PP.IAI.IV/2018
PTN/S : Universitas Pakuan Program Studi : BIOLOGI
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