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Repository Universitas Pakuan Electronic Journal Karya Ilmiah Dosen Journal Online Mahasiswa
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Detail Karya Ilmiah Dosen

Karlina Saptanti 1, Leny Heliawati 2, Elvira Hermawati 1, Yana M Syah 3

Judul : Pentacyclic triterpenes from the leaves extract of Sandoricum koetjape
Abstrak :

Three new pentacyclic triterpenes, trivially named sandkoetjapic acids A-C (1-3), have been isolated from the leaves extract of Sandoricum koetjape, along with the known triterpenes 3-oxo-olean-12-en-29-oic (4), bryonolic (5), and bryononic (6) acids. The structures of the new triterpenes were determined mainly by NMR spectroscopic and mass spectroscopic data. The isolation of these pentacyclic triterpenes in the plant's leaves is for the first time. Preliminary biological evaluation of 1-6 was done against eight receptor tyrosine kinases (RTKs), including EGFR, HER2, HER4 (epidermal growth factor receptor), IGF1R, InsR (insulin receptor), KDR (kinase insert domain receptor), and PDGFRα/-β (platelet-derived growth factor receptor), and their inhibitory properties against β-lactamase. The results showed that none of them were active both as the inhibitors of these RTKs and β-lactamase
Tahun : 2022 Media Publikasi : Jurnal Internasional
Kategori : Jurnal No/Vol/Tahun : - / - / 2022
ISSN/ISBN : -
PTN/S : universitas pakuan Program Studi : PENDIDIKAN ILMU PENGETAHUAN ALAM
Bibliography :

    1. Muellner AN, Samuel R, Chase MW, Coleman A, Stuessy TF (2008) An evaluation of tribe and generic relationship in Melioideae (Meliaceae) based on nuclear ITS Ribosomal DNA. Taxon 57:98–108
    1. Efdi M, Ninomiya M, Suryani E, Tanaka K, Ibrahim S, Watanabe K, Koketsu M (2012) Sentulic acid: a cytotoxic ring A-seco triterpenoid from Sandoricum koetjape Merr. Bioorg Med Chem Lett 22:4242–4245 - DOI
    1. Kaneda N, Pezzuto JM, Kinghorn D, Farnsworth NR (1992) Plant anticancer agents, L. cytotoxic triterpenes from Sandoricum koetjape stems. J Nat Prod 55:654–659 - DOI
    1. King FE, Morgan JWW (1960) The chemistry of extractives from hardwoods. Part XXX. The constitution of katonic acid, a triterpene from Sandoricum indicum. J. Chem. Soc. 4738–4747
    1. Sim KY, Lee HT (1972) Triterpenoid and other constituents from Sandoricum indicum. Phytochemistry 11:3341–3343 - DOI
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