Repository Universitas Pakuan

Detail Karya Ilmiah Dosen

Karlina Saptanti 1, Leny Heliawati 2, Elvira Hermawati 1, Yana M Syah 3

Judul : Pentacyclic triterpenes from the leaves extract of Sandoricum koetjape
Abstrak :

Three new pentacyclic triterpenes, trivially named sandkoetjapic acids A-C (1-3), have been isolated from the leaves extract of Sandoricum koetjape, along with the known triterpenes 3-oxo-olean-12-en-29-oic (4), bryonolic (5), and bryononic (6) acids. The structures of the new triterpenes were determined mainly by NMR spectroscopic and mass spectroscopic data. The isolation of these pentacyclic triterpenes in the plant's leaves is for the first time. Preliminary biological evaluation of 1-6 was done against eight receptor tyrosine kinases (RTKs), including EGFR, HER2, HER4 (epidermal growth factor receptor), IGF1R, InsR (insulin receptor), KDR (kinase insert domain receptor), and PDGFRα/-β (platelet-derived growth factor receptor), and their inhibitory properties against β-lactamase. The results showed that none of them were active both as the inhibitors of these RTKs and β-lactamase

Tahun : 2022 Media Publikasi : Jurnal Internasional
Kategori : Jurnal No/Vol/Tahun : - / - / 2022
PTN/S : universitas pakuan Program Studi : PENDIDIKAN ILMU PENGETAHUAN ALAM
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