Repository Universitas Pakuan

Detail Karya Ilmiah Dosen

Dyah Ayu Rachmadhaningtiyas, Leny Heliawati, Elvira Hermawati , And Yana Maolana Syah,

Judul : A Cipadesin Limonoid and a Tirucallane Triterpene from the Fruit of Sandoricum koetjape and their Inhibitory Properties against Receptor Tyrosine Kinases

Abstrak :
ï€ A new cipadesin limonoid, i.e. 3-epi-cipadonoid C (1), and a new tirucallane triterpene, i.e. hispidol B 3-palmitate (3), have been isolated from the seeds and fruit peels extract of Sandoricum koetjape, respectively. Along with these compounds the known limonoid, cipaferen G (2), and two pentacyclic triterpenes, bryonolic (4) and bryononic (5) acids, were also isolated. The strucrures of the new compounds were elucidated by the analysis of NMR and mass spectral data. Compounds 1 - 5 were evaluated as the inhibitor of receptor tyrosine kinases (EGFR, Epidermal Growth Factor Receptor; HER2, HER4, Human Epidermal growth factor Receptor 2, -4; IGFR, Insulin-like Growth Factor Receptor; InsR, Insulin Receptor; KDR, Kinase insert Domain Receptor; PDGFRα, and PDGFRï¢, Platelet-Derived Growth Factor Receptor-α and -ï¢). The results showed only 1 and 3 that have weak activity against InsR

Tahun : 2021 Media Publikasi : Jurnal Internasional

Kategori : Jurnal No/Vol/Tahun : 2 / 27 / 2021

ISSN/ISBN : https://doi.org/10.20307/nps.2021.27.2.134 134 A

PTN/S : Universitas Pakuan Program Studi : KIMIA

Bibliography :
(1) Meegan, M. J.; O’Boyle, N. M. Pharmaceuticals 2019, 12, 134. (2) Pottier, C.; Fresnais, M.; Gilon, M.; Jérusalem, G.; Longuespée, R.; Sounni, N. E. Cancers 2020, 12, 731. (3) Ferguson, F.; Gray, N. S. Nat. Rev. Drug Discov. 2018, 17, 353-377. (4) Jiao, Q.; Bi, L.; Ren, Y.; Song, S.; Wang, Q.; Wang, Y. S. Mol. Cancer 2018, 17, 36. (5) Yin, B.; Fang, D. M.; Zhou, X. L.; Gao, F. Eur. J. Med. Chem. 2019, 182, 111664. (6) Pejin, B.; JovanoviÄ‡, K. K.; MojoviÄ‡, M.; SaviÄ‡, A. G . Curr. Top. Med. Chem. 2013, 13, 2745-2766. (7) Efdi, M.; Ninomiya, M.; Suryani, E.; Tanaka, K.; Ibrahim, S.; Watanabe, K.; Koketsu, M. Bioorg. Med. Chem. Lett. 2012, 22, 4242- 4245. (8) Bumi, M. B.; Heliawaty, L.; Hermawati, E.; Syah, Y. M. J. Nat. Med. 2019, 73, 641-647. (9) Heliawati, L.; Khatimah, H.; Hermawati, E.; Syah, Y. M. Nat. Prod. Sci. 2020, 26, 345-350. (10) Hermawati, E.;. Ellita, S. D.; Juliawaty, L. D.; Hakim, E. H.; Syah, Y. M.; Ishikawa, H. J. Nat. Med. 2021, 75, 217-222. (11) Mistry, B. D. Ultraviolet spectroscopy in A handbook of spectroscopic data chemistry; Oxford Book Company: India, 2009, pp 3- 5. (12) Tan, Q. G.; Luo, X. D. Chem. Rev. 2011, 111, 7437-7522. (13) Fang, X.; Zhang, Q.; Tan, C. J.; Mu, S. Z.; Lu, Y.; Lu, Y. B.; Zheng, Q. T.; Di, Y. T.; Hao, X. J. Tetrahedron 2009, 65, 7408-7414. (14) Siva, B.; Poornima, B.; Venkanna, A.; Prasad, K. R.; Sridhar, B.; Nayak, V. L.; Ramakrishna, S.; Babu, K. S. Phytochemistry 2014, 98, 174-182. (15) Jolad, S. D.; Hoffmann, J. J.; Schram, K. H.; Cole, J. R.; Tempesta, M. S.; Bates, R. B. J. Org. Chem. 1981, 46, 4085-4088. (16) MacChesney, J. D.; Dou, J.; Sindelar, R. D.; Goins, D. K.; Walker, L. A.; Rogers, R. D. J. Chem. Cryst. 1997, 27, 283-290. (17) Sim, K. Y.; Lee, H. T. Phytochemistry 1972, 11, 3341-3343. (18) De Meyts, P.; Whittaker, J. Nat. Rev. Drug Discov. 2002, 1, 769- 783

URL : https://drive.google.com/drive/folders/1oAcv8dPvbePjsIaEUAsLWLm9rNuRox2D

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Detail Karya Ilmiah Dosen

Dyah Ayu Rachmadhaningtiyas, Leny Heliawati, Elvira Hermawati , And Yana Maolana Syah,

Judul	:	A Cipadesin Limonoid and a Tirucallane Triterpene from the Fruit of Sandoricum koetjape and their Inhibitory Properties against Receptor Tyrosine Kinases
Abstrak	:	ï€ A new cipadesin limonoid, i.e. 3-epi-cipadonoid C (1), and a new tirucallane triterpene, i.e. hispidol B 3-palmitate (3), have been isolated from the seeds and fruit peels extract of Sandoricum koetjape, respectively. Along with these compounds the known limonoid, cipaferen G (2), and two pentacyclic triterpenes, bryonolic (4) and bryononic (5) acids, were also isolated. The strucrures of the new compounds were elucidated by the analysis of NMR and mass spectral data. Compounds 1 - 5 were evaluated as the inhibitor of receptor tyrosine kinases (EGFR, Epidermal Growth Factor Receptor; HER2, HER4, Human Epidermal growth factor Receptor 2, -4; IGFR, Insulin-like Growth Factor Receptor; InsR, Insulin Receptor; KDR, Kinase insert Domain Receptor; PDGFRα, and PDGFRï¢, Platelet-Derived Growth Factor Receptor-α and -ï¢). The results showed only 1 and 3 that have weak activity against InsR
Tahun	:	2021	Media Publikasi	:	Jurnal Internasional
Kategori	:	Jurnal	No/Vol/Tahun	:	2 / 27 / 2021
ISSN/ISBN	:	https://doi.org/10.20307/nps.2021.27.2.134 134 A
PTN/S	:	Universitas Pakuan	Program Studi	:	KIMIA
Bibliography	:	(1) Meegan, M. J.; O’Boyle, N. M. Pharmaceuticals 2019, 12, 134. (2) Pottier, C.; Fresnais, M.; Gilon, M.; Jérusalem, G.; Longuespée, R.; Sounni, N. E. Cancers 2020, 12, 731. (3) Ferguson, F.; Gray, N. S. Nat. Rev. Drug Discov. 2018, 17, 353-377. (4) Jiao, Q.; Bi, L.; Ren, Y.; Song, S.; Wang, Q.; Wang, Y. S. Mol. Cancer 2018, 17, 36. (5) Yin, B.; Fang, D. M.; Zhou, X. L.; Gao, F. Eur. J. Med. Chem. 2019, 182, 111664. (6) Pejin, B.; JovanoviÄ‡, K. K.; MojoviÄ‡, M.; SaviÄ‡, A. G . Curr. Top. Med. Chem. 2013, 13, 2745-2766. (7) Efdi, M.; Ninomiya, M.; Suryani, E.; Tanaka, K.; Ibrahim, S.; Watanabe, K.; Koketsu, M. Bioorg. Med. Chem. Lett. 2012, 22, 4242- 4245. (8) Bumi, M. B.; Heliawaty, L.; Hermawati, E.; Syah, Y. M. J. Nat. Med. 2019, 73, 641-647. (9) Heliawati, L.; Khatimah, H.; Hermawati, E.; Syah, Y. M. Nat. Prod. Sci. 2020, 26, 345-350. (10) Hermawati, E.;. Ellita, S. D.; Juliawaty, L. D.; Hakim, E. H.; Syah, Y. M.; Ishikawa, H. J. Nat. Med. 2021, 75, 217-222. (11) Mistry, B. D. Ultraviolet spectroscopy in A handbook of spectroscopic data chemistry; Oxford Book Company: India, 2009, pp 3- 5. (12) Tan, Q. G.; Luo, X. D. Chem. Rev. 2011, 111, 7437-7522. (13) Fang, X.; Zhang, Q.; Tan, C. J.; Mu, S. Z.; Lu, Y.; Lu, Y. B.; Zheng, Q. T.; Di, Y. T.; Hao, X. J. Tetrahedron 2009, 65, 7408-7414. (14) Siva, B.; Poornima, B.; Venkanna, A.; Prasad, K. R.; Sridhar, B.; Nayak, V. L.; Ramakrishna, S.; Babu, K. S. Phytochemistry 2014, 98, 174-182. (15) Jolad, S. D.; Hoffmann, J. J.; Schram, K. H.; Cole, J. R.; Tempesta, M. S.; Bates, R. B. J. Org. Chem. 1981, 46, 4085-4088. (16) MacChesney, J. D.; Dou, J.; Sindelar, R. D.; Goins, D. K.; Walker, L. A.; Rogers, R. D. J. Chem. Cryst. 1997, 27, 283-290. (17) Sim, K. Y.; Lee, H. T. Phytochemistry 1972, 11, 3341-3343. (18) De Meyts, P.; Whittaker, J. Nat. Rev. Drug Discov. 2002, 1, 769- 783
URL	:	https://drive.google.com/drive/folders/1oAcv8dPvbePjsIaEUAsLWLm9rNuRox2D