Repository Universitas Pakuan

Detail Karya Ilmiah Dosen

Trirakhma Sofihidayati, Siti Mahyuni

Judul : AKTIVITAS ANTIBAKTERI EKSTRAK METANOL, EKSTRAK FRAKSI N-HEKSAN DAN EKSTRAK N-HEKSAN DAUN FILICIUM DECIPIENS TERHADAP BAKTERI STAPHYLOCOCCUS AUREUS DAN BAKTERI BACILLUS SUBTILIS

Abstrak :
The previous study shows ethanol extract of Filicium decipiens leaf possesses a strong antibacterial activity against Staphylococcus aureus, but there have been no study of the antibacterial activity with different solvents. The purpose of this study was to determine the antibacterial activities of methanol, n-hexane fraction of methanol, and n-hexane extract of F. decipiens leaves against S. aureus and Bacillus subtilis bacteria. Extraction was carried out by soxletation method using methanol and n-hexane solvent. The antibacterial activity test was done by measuring the minimum inhibitory concentration (MIC) and zone of Inhibition. The results showed that methanol extract did not have activity either against S. aureus bacteria or against B. subtilis. N-hexane extract which was fractionated from methanol extract had no activity against B. subtilis but showed moderate activity against S. aureus with 9 mm inhibition diameter at an extract concentration of 40%. N-hexane extract has very strong antibacterial activity against S. aureus with inhibition diameter reaching 21 mm at extract concentration of 30% and showing strong activity against B. subtilis bacteria with inhibition diameter of 10 mm at extract concentration of 30%. It can be concluded that n-hexane extract from F. decipiens has a potent as natural antibiotic material.

Tahun : 2020 Media Publikasi : Jurnal Nasional Blm Akreditasi

Kategori : Jurnal No/Vol/Tahun : 5 / 2 / 2020

ISSN/ISBN : e-ISSN : 2442-5257

PTN/S : Universitas Pakuan Program Studi : FARMASI

Bibliography :
Mulholland EK, Adegbola. Bacterial infections A major cause of death among children in Africa N.Engl.J.Med .
2005; 352 (1):75 7
2. FarjanaA, ZerinN, Kabir Md. S.Antimicrobial activity of medicinal plant leaf extracts against pathogenic bacteria Asian .Pac.J.Trop.Dis Dis. 2014; 4(2):, Suppl. 2. P. S920-3.
3. Thiripurasundari N, Vinodhkumar T, Ramanathan G. Antimicrobial potential of medicinal plant extracts against
human pathogens. Int. Res J Pharm. App Sci. 2013; 3(4):107 9
4. Mahyuni S, Sofihidayati S. Kadar saponin dan aktivitas antibakteri ekstrak daun Filiciumdecipiens (Wight&Arn.)
Thwaites terhadap Staphylococcus aureus , Escherichia coli dan Candida albicans . Fitofarmaka Jurnal Ilmiah
Farmasi. 2018; 8(2):20 7.

URL : https://garuda.ristekbrin.go.id/journal/view/10483

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Detail Karya Ilmiah Dosen

Trirakhma Sofihidayati, Siti Mahyuni

Judul	:	AKTIVITAS ANTIBAKTERI EKSTRAK METANOL, EKSTRAK FRAKSI N-HEKSAN DAN EKSTRAK N-HEKSAN DAUN FILICIUM DECIPIENS TERHADAP BAKTERI STAPHYLOCOCCUS AUREUS DAN BAKTERI BACILLUS SUBTILIS
Abstrak	:	The previous study shows ethanol extract of Filicium decipiens leaf possesses a strong antibacterial activity against Staphylococcus aureus, but there have been no study of the antibacterial activity with different solvents. The purpose of this study was to determine the antibacterial activities of methanol, n-hexane fraction of methanol, and n-hexane extract of F. decipiens leaves against S. aureus and Bacillus subtilis bacteria. Extraction was carried out by soxletation method using methanol and n-hexane solvent. The antibacterial activity test was done by measuring the minimum inhibitory concentration (MIC) and zone of Inhibition. The results showed that methanol extract did not have activity either against S. aureus bacteria or against B. subtilis. N-hexane extract which was fractionated from methanol extract had no activity against B. subtilis but showed moderate activity against S. aureus with 9 mm inhibition diameter at an extract concentration of 40%. N-hexane extract has very strong antibacterial activity against S. aureus with inhibition diameter reaching 21 mm at extract concentration of 30% and showing strong activity against B. subtilis bacteria with inhibition diameter of 10 mm at extract concentration of 30%. It can be concluded that n-hexane extract from F. decipiens has a potent as natural antibiotic material.
Tahun	:	2020	Media Publikasi	:	Jurnal Nasional Blm Akreditasi
Kategori	:	Jurnal	No/Vol/Tahun	:	5 / 2 / 2020
ISSN/ISBN	:	e-ISSN : 2442-5257
PTN/S	:	Universitas Pakuan	Program Studi	:	FARMASI
Bibliography	:	Mulholland EK, Adegbola. Bacterial infections A major cause of death among children in Africa N.Engl.J.Med . 2005; 352 (1):75 7 2. FarjanaA, ZerinN, Kabir Md. S.Antimicrobial activity of medicinal plant leaf extracts against pathogenic bacteria Asian .Pac.J.Trop.Dis Dis. 2014; 4(2):, Suppl. 2. P. S920-3. 3. Thiripurasundari N, Vinodhkumar T, Ramanathan G. Antimicrobial potential of medicinal plant extracts against human pathogens. Int. Res J Pharm. App Sci. 2013; 3(4):107 9 4. Mahyuni S, Sofihidayati S. Kadar saponin dan aktivitas antibakteri ekstrak daun Filiciumdecipiens (Wight&Arn.) Thwaites terhadap Staphylococcus aureus , Escherichia coli dan Candida albicans . Fitofarmaka Jurnal Ilmiah Farmasi. 2018; 8(2):20 7.
URL	:	https://garuda.ristekbrin.go.id/journal/view/10483