TRI SAPTARI HARYANI, TRIASTINURMIATININGSIH, BINA LOHITA SARI, DWI LIANA HANURA

Judul	:	INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH
Abstrak	:	Antibacterial activity of Padina australis extract tablet against Escherichia coli Padina australis (P. australis) is one of the seaweed that have a potential as antibacterial Escherichia coli (E. coli). Triterpenoids and steroids are secondary metabolites compounds contained in seaweed, and has a variety of activities as bactericide, and hypo-allergenic. This study aims to establish tablet formulation and determine the activity and effectiveness against E.coli bacteria causing diarrheal disease. The formulation was prepared with these treatment: formula I (20 %), formula II (25 %), formula III (30 %), formula IV as negative control in the form of tablet with no active ingredient, and a positive control using amoxycillin (10 ppm). The activity and effectiveness was tested by calculating diameter of inhibition zone–a clear zone resulting from the three formulas, negative, and positive control using Kirby-Bauer method. The result shows that the formulation with active ingredient of 30 % of P. australis extract has an inhibitory activity of 7.7 mm and effective as antibacterial E. coli. Thus it can be concluded that the formulation of 30 % of P. australis extract tablet is the most effective formula as antibacterial E. coli causing diarrhea disease. Keyword: Padina australis, tablets, antibacterial, Escherichia coli
Tahun	:	2020	Media Publikasi	:	Jurnal Internasional
Kategori	:	Jurnal	No/Vol/Tahun	:	ISSUE 3 / 12 / 2020
ISSN/ISBN	:	0975-2366
PTN/S	:	Universitas Pakuan	Program Studi	:	BIOLOGI
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URL	:	http://ijpronline.com/ViewIssue.aspx?Volume=26&Issue=58