Repository Universitas Pakuan

Detail Karya Ilmiah Dosen

Novi Fajar Utami, Prasetyorini, Rike Khaerunissa, Indria Pramitasari, Ade Herbayani

Judul : SCREENING OF MANGO LEAVES (MANGIFERA INDICA L.) VARIETIES IN INDONESIA FOR ANTIBACTERIAL ACTIVITY IN STAPHYLOCOCCUS AUREUS

Abstrak :
Acne is a common chronic skin disease that involves the blockage and inflammation of the polysebase unit which causes one of them is the bacterial
infection of Staphylococcus aureus. In Indonesia, there are several varieties of mango plants (Mangifera indica L), including gedong mango, apple
mango, simanalagi mango, and arumanis mango. The leaves of the mango are very abundant and have not been widely used by Indonesian people as
traditional medicine as bacterial infection of Staphylococcus aureus. The main objective has investigated the presence of phytochemical constituents
and antibacterial activity from several varieties of mango in Indonesia. Mango leaves varieties were extracted with 96% ethanol and screened for
phytochemical constituents with standard procedure. The antibacterial activities of some mango leaves varieties were examined by minimum inhibitory
concentration and inhibitory width by agar well diffusion and dilution method. Based on the results of phytochemical testing, four varieties of mango
leaves in Indonesia, contain volatile oils, carbohydrates, glycosides, sterols, triterpenes, flavonoids, coumarins, tannins and saponins and the absence of
anthraquinones, alkaloids and cardiac glycosides. In the antibacterial activity, arumanis mango shows the most potent inhibitory activity against
Staphylococcus aureus with a MIC value of 40% and the width of the inhibitory value of 3.60 mm at a concentration of 40%.
Keyword: Mangifera indica L, Indonesia, Staphylococcus aureus, Leaves, Width of Inhibition

Tahun : 2020 Media Publikasi : Jurnal Internasional

Kategori : Jurnal No/Vol/Tahun : 2 / 11 / 2020

ISSN/ISBN : 10.7897/2277-4343.110234

PTN/S : Universitas Pakuan Program Studi : FARMASI

Bibliography :
1. Svensson, A., Ofenloch, R.F., Bruze, M., Naldi, L.,
Cazzaniga, S., Elsner, P., Goncalo, M., Schuttelaar, M.-L.A.,
Diepgen, T.L. Prevalence of skin disease in a populationbased
sample of adults from five European countries. Br. J.
Dermatol. 2018. 178, 1111–1118.
2. Jantarat, C., Sirathanarun, P., Chuchue, T., Konpian, A.,
Sukkua, G., Wongprasert, P., Jantarat, C., Sirathanarun, P.,
Chuchue, T., Konpian, A. In Vitro Antimicrobial Activity of
Gel Containing the Herbal Ball Extract against
Propionibacterium acnes. Sci. Pharm. 2018. 86, 8.
3. Sinha, P., Srivastava, S., Mishra, N., Yadav, N.P. New
Perspectives on Antiacne Plant Drugs: Contribution to
Modern Therapeutics. Available online:
https://www.hindawi.com/journals/bmri/2014/301304/abs/
(accessed on 12 January 2019).
4. Dessinioti, C. Zouboulis, C.C., Katsambas, A.D., Kligman,
A.M. Acne Pathogenesis: What We Have Learned Over the
Years. In Pathogenesis and Treatment of Acne and Rosacea;
Eds.; Springer: Berlin/Heidelberg, Germany, 2014. pp. 61–
70. ISBN 978-3-540-69375-8.
5. Isard, O., Knol, A.C., Ariès, M.F., Nguyen, J.M., Khammari,
A., Castex-Rizzi, N., Dréno, B. Propionibacterium acnes
activates the IGF-1/IGF-1R system in the epidermis and
induces keratinocyte proliferation. J. Investig. Dermatol.
2011. 131, 59–66.
6. Chandrashekhar B.S., Anitha M., Ruparelia M., Vaidya P.,
Aamir R., Shah S. Tretinoin nanogel 0.025% versus
conventional gel 0.025% in patients with acne vulgaris: A
randomized, active controlled, multicen- tre, parallel group,
phase iv clinical trial. J Clin Diagn Res.2015. 9(1): WC04-9.
7. Degitz, K., Ochsendorf, F. Acne. J. Dtsch. Dermatol. Ges.
2017. 15, 709–722.
8. Larkin, E.A., Carman, R.J., Krakauer, T., Stiles, B.G.
Staphylococcus aureus: The toxic presence of a pathogen
extraordinaire. Curr. Med. Chem. 2009. 16, 4003–4019.
Novi Fajar Utami et al / Int. J. Res. Ayurveda Pharm. 11 (2), 2020
80
9. R. Hirano, T. H., Watanabe. Myanmar mango landraces
reveal genetic uniqueness over common cultivars from
Florida, India, and Southeast Asia. Genome. 2010. vol. 53,
no. 4, pp. 321–330.
10. Shah, K.A., Patel M.B., Patel R.J., Parmar, P.K. Mangifera
indica (mango). Pharmacognosy Review. 2010. 4(7): 42-
48S.M.Y.2019
11. Berardini N., Fezer R., Conrad J., Beifuss U., Carl R.,
Schieber. Screening of mango (Mangifera indica L.) cultivars
for their contents of flavonol O- and xanthone C-glycosides,
anthocyanins, and pectin. Journal of Agricultural and Food
Chemistry. 2005. vol. 53, no. 5, pp. 1563–1570.
12. Ling, L. T., Yap, S., Radhakrishnan, A. K., Subramaniam, T.,
Cheng, H. M., Palanisamy, U.D. Standardised Mangifera
indica extract is an ideal antioxidant. Food Chemistry. 2009.
113, 1154–1159.
13. Bereksi, M. S., Hassaïne, H., Bekhechi, C., & Abdelouahid,
D. E. Evaluation of antibacterial activity of some medicinal
plants extracts commonly used in Algerian traditional
medicine against some pathogenic bacteria. Pharmacognosy
Journal. 2018. 10(3).
14. Dellière, S., Verdurme, L., Bigot, J., Dannaoui, E., Senghor,
Y., Botterel, F., Guitard, J. Comparison of the MICs Obtained
by Gradient Concentration Strip and EUCAST Methods for
Four Azole Drugs and Amphotericin B Against azolesusceptible
and-resistant Aspergillus section Fumigati
clinical isolates. Antimicrobial Agents and Chemotherapy.
2019. Vol 8.
15. Ditjen POM. Supplement 1 Pharmakopea Herbal Indonesia.
Jakarta. 2008.
16. Dorta E, Gonzales M, Gloria Lobo M, Moreno Sanchez C, de
Ancos.Screening of phenolic compounds in by-product
extracts from mangoes (Mangifera indica L.) by HPLC-ESIQTOF-
MS and multivariate analysis for use as a food
ingredient.Food research international. 2014. 54:56
17. Jain, P., Bansal,D., Bhasin P., Anjali. Antimicrobial activity
and phytochemical screening of five wild plants against
Escherichia coli, Bacillus subtilis and Staphylococcus aureus.
Journal of pharmacy research. 2010. 3(6):1260-1262
18. Kuete, V., Ngameni, B., Mbaveng, A. T., Ngadjui, B., Meyer,
J. M., Lall, N. Evaluation of Flavonoids from Dorstenia
Barteri for their Anti mycobacterial, Antigonorrheal and
Anti-reverse Transcriptase Activities. Actatropica, 2010.
116(1), 100-104.
19. Madduluri, Suresh. Rao, K. Babu.
Sitaram, B. In Vitro Evaluation of Antibacterial Activity of
Five Indegenous Plants Extract Against Five Bacteria
Pathogens of Human. International Journal of Pharmacy and
Pharmaceutical Sciences. 2010. 5 (4): 679-684
20. Wang Q, Wang H, Xie M. Antibacterial mechanism of
soybean isoflavone on Staphylococcus aureus. Arch
Microbiol. 2010;192:893–8.
21. Chinnam N, Dadi P.K., Sabri S.A., Internasional M, Kabir
M.A, Internasional Z. Dietary bioflavonoids inhibit
Escherichia coli ATP synthase in a differential manner. Int J
Biol Macromol 2010;46:478–86.
22. Sahrawat A, Pal S, Shahi SK. Antibacterial activity of
Mangifera indica (mango) leaves against drug resistant
bacterial strains. Internasional Journal of Advanced
Research. 2013; 1(6):82-86.
23. Savikin K, Menkovic N, Zdunic G, Stevic T, Radanovic D.
Jankovic T. Antimicrobial activity of Gentiana lutea L.
Extracts. Naturforsch. 2009; 64:339-342.
Cite this article as:
Novi Fajar Utami et al. Screening of mango leaves (Mangifera
indica L.) varieties in Indonesia for antibacterial activity in
Staphylococcus aureus. Int. J. Res. Ayurveda Pharm.
2020;11(2):77-80 http://dx.doi.org/10.7897/2277-4343.110234

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Detail Karya Ilmiah Dosen

Novi Fajar Utami, Prasetyorini, Rike Khaerunissa, Indria Pramitasari, Ade Herbayani

Judul	:	SCREENING OF MANGO LEAVES (MANGIFERA INDICA L.) VARIETIES IN INDONESIA FOR ANTIBACTERIAL ACTIVITY IN STAPHYLOCOCCUS AUREUS
Abstrak	:	Acne is a common chronic skin disease that involves the blockage and inflammation of the polysebase unit which causes one of them is the bacterial infection of Staphylococcus aureus. In Indonesia, there are several varieties of mango plants (Mangifera indica L), including gedong mango, apple mango, simanalagi mango, and arumanis mango. The leaves of the mango are very abundant and have not been widely used by Indonesian people as traditional medicine as bacterial infection of Staphylococcus aureus. The main objective has investigated the presence of phytochemical constituents and antibacterial activity from several varieties of mango in Indonesia. Mango leaves varieties were extracted with 96% ethanol and screened for phytochemical constituents with standard procedure. The antibacterial activities of some mango leaves varieties were examined by minimum inhibitory concentration and inhibitory width by agar well diffusion and dilution method. Based on the results of phytochemical testing, four varieties of mango leaves in Indonesia, contain volatile oils, carbohydrates, glycosides, sterols, triterpenes, flavonoids, coumarins, tannins and saponins and the absence of anthraquinones, alkaloids and cardiac glycosides. In the antibacterial activity, arumanis mango shows the most potent inhibitory activity against Staphylococcus aureus with a MIC value of 40% and the width of the inhibitory value of 3.60 mm at a concentration of 40%. Keyword: Mangifera indica L, Indonesia, Staphylococcus aureus, Leaves, Width of Inhibition
Tahun	:	2020	Media Publikasi	:	Jurnal Internasional
Kategori	:	Jurnal	No/Vol/Tahun	:	2 / 11 / 2020
ISSN/ISBN	:	10.7897/2277-4343.110234
PTN/S	:	Universitas Pakuan	Program Studi	:	FARMASI
Bibliography	:	1. Svensson, A., Ofenloch, R.F., Bruze, M., Naldi, L., Cazzaniga, S., Elsner, P., Goncalo, M., Schuttelaar, M.-L.A., Diepgen, T.L. Prevalence of skin disease in a populationbased sample of adults from five European countries. Br. J. Dermatol. 2018. 178, 1111–1118. 2. Jantarat, C., Sirathanarun, P., Chuchue, T., Konpian, A., Sukkua, G., Wongprasert, P., Jantarat, C., Sirathanarun, P., Chuchue, T., Konpian, A. In Vitro Antimicrobial Activity of Gel Containing the Herbal Ball Extract against Propionibacterium acnes. Sci. Pharm. 2018. 86, 8. 3. Sinha, P., Srivastava, S., Mishra, N., Yadav, N.P. New Perspectives on Antiacne Plant Drugs: Contribution to Modern Therapeutics. Available online: https://www.hindawi.com/journals/bmri/2014/301304/abs/ (accessed on 12 January 2019). 4. Dessinioti, C. Zouboulis, C.C., Katsambas, A.D., Kligman, A.M. Acne Pathogenesis: What We Have Learned Over the Years. In Pathogenesis and Treatment of Acne and Rosacea; Eds.; Springer: Berlin/Heidelberg, Germany, 2014. pp. 61– 70. ISBN 978-3-540-69375-8. 5. Isard, O., Knol, A.C., Ariès, M.F., Nguyen, J.M., Khammari, A., Castex-Rizzi, N., Dréno, B. Propionibacterium acnes activates the IGF-1/IGF-1R system in the epidermis and induces keratinocyte proliferation. J. Investig. Dermatol. 2011. 131, 59–66. 6. Chandrashekhar B.S., Anitha M., Ruparelia M., Vaidya P., Aamir R., Shah S. Tretinoin nanogel 0.025% versus conventional gel 0.025% in patients with acne vulgaris: A randomized, active controlled, multicen- tre, parallel group, phase iv clinical trial. J Clin Diagn Res.2015. 9(1): WC04-9. 7. Degitz, K., Ochsendorf, F. Acne. J. Dtsch. Dermatol. Ges. 2017. 15, 709–722. 8. Larkin, E.A., Carman, R.J., Krakauer, T., Stiles, B.G. Staphylococcus aureus: The toxic presence of a pathogen extraordinaire. Curr. Med. Chem. 2009. 16, 4003–4019. Novi Fajar Utami et al / Int. J. Res. Ayurveda Pharm. 11 (2), 2020 80 9. R. Hirano, T. H., Watanabe. Myanmar mango landraces reveal genetic uniqueness over common cultivars from Florida, India, and Southeast Asia. Genome. 2010. vol. 53, no. 4, pp. 321–330. 10. Shah, K.A., Patel M.B., Patel R.J., Parmar, P.K. Mangifera indica (mango). Pharmacognosy Review. 2010. 4(7): 42- 48S.M.Y.2019 11. Berardini N., Fezer R., Conrad J., Beifuss U., Carl R., Schieber. Screening of mango (Mangifera indica L.) cultivars for their contents of flavonol O- and xanthone C-glycosides, anthocyanins, and pectin. Journal of Agricultural and Food Chemistry. 2005. vol. 53, no. 5, pp. 1563–1570. 12. Ling, L. T., Yap, S., Radhakrishnan, A. K., Subramaniam, T., Cheng, H. M., Palanisamy, U.D. Standardised Mangifera indica extract is an ideal antioxidant. Food Chemistry. 2009. 113, 1154–1159. 13. Bereksi, M. S., Hassaïne, H., Bekhechi, C., & Abdelouahid, D. E. Evaluation of antibacterial activity of some medicinal plants extracts commonly used in Algerian traditional medicine against some pathogenic bacteria. Pharmacognosy Journal. 2018. 10(3). 14. Dellière, S., Verdurme, L., Bigot, J., Dannaoui, E., Senghor, Y., Botterel, F., Guitard, J. Comparison of the MICs Obtained by Gradient Concentration Strip and EUCAST Methods for Four Azole Drugs and Amphotericin B Against azolesusceptible and-resistant Aspergillus section Fumigati clinical isolates. Antimicrobial Agents and Chemotherapy. 2019. Vol 8. 15. Ditjen POM. Supplement 1 Pharmakopea Herbal Indonesia. Jakarta. 2008. 16. Dorta E, Gonzales M, Gloria Lobo M, Moreno Sanchez C, de Ancos.Screening of phenolic compounds in by-product extracts from mangoes (Mangifera indica L.) by HPLC-ESIQTOF- MS and multivariate analysis for use as a food ingredient.Food research international. 2014. 54:56 17. Jain, P., Bansal,D., Bhasin P., Anjali. Antimicrobial activity and phytochemical screening of five wild plants against Escherichia coli, Bacillus subtilis and Staphylococcus aureus. Journal of pharmacy research. 2010. 3(6):1260-1262 18. Kuete, V., Ngameni, B., Mbaveng, A. T., Ngadjui, B., Meyer, J. M., Lall, N. Evaluation of Flavonoids from Dorstenia Barteri for their Anti mycobacterial, Antigonorrheal and Anti-reverse Transcriptase Activities. Actatropica, 2010. 116(1), 100-104. 19. Madduluri, Suresh. Rao, K. Babu. Sitaram, B. In Vitro Evaluation of Antibacterial Activity of Five Indegenous Plants Extract Against Five Bacteria Pathogens of Human. International Journal of Pharmacy and Pharmaceutical Sciences. 2010. 5 (4): 679-684 20. Wang Q, Wang H, Xie M. Antibacterial mechanism of soybean isoflavone on Staphylococcus aureus. Arch Microbiol. 2010;192:893–8. 21. Chinnam N, Dadi P.K., Sabri S.A., Internasional M, Kabir M.A, Internasional Z. Dietary bioflavonoids inhibit Escherichia coli ATP synthase in a differential manner. Int J Biol Macromol 2010;46:478–86. 22. Sahrawat A, Pal S, Shahi SK. Antibacterial activity of Mangifera indica (mango) leaves against drug resistant bacterial strains. Internasional Journal of Advanced Research. 2013; 1(6):82-86. 23. Savikin K, Menkovic N, Zdunic G, Stevic T, Radanovic D. Jankovic T. Antimicrobial activity of Gentiana lutea L. Extracts. Naturforsch. 2009; 64:339-342. Cite this article as: Novi Fajar Utami et al. Screening of mango leaves (Mangifera indica L.) varieties in Indonesia for antibacterial activity in Staphylococcus aureus. Int. J. Res. Ayurveda Pharm. 2020;11(2):77-80 http://dx.doi.org/10.7897/2277-4343.110234
URL	: