|Judul||:||Study of Hypoglicemic Effect and Acute Toxicity of Ethyl Acetat Fraction Tofu Residue|
The study aimed to investigate oral glucose tolerance test (OGTT) and acute toxicity of Ethyl Acetat Fraction Tofu Residue (EAFTR) on DDY mice. Methods: EAFTR (200 mg/kg b.w) was prepared and administered orally to experimental animals used. The hypoglycemic effects of EAFTR on normal mice and orally glucose (3 g/kg bw) induced hyperglycemic mice were compared with aquadest, glibenclamide and dry tofu residue (200 mg/kg b.w). EAFTR was administered and blood glucose level was obtained by pricking the tail vein using glucometer at time -30, 0, 30, 60, 120 minutes. Hypoglicemic effect evaluated by Area Under Curve (AUC) measurement. The EAFTR was tested for acute toxicity in mice at a dose of 50, 500 and 2,000 mg/kg b.w. p.o once daily for 14 days. Results: The AUC of EAFTR treated groups were not different with control, Metformin treated and dry tofu residue. All doses of the EAFTR did not exert any sign or symptom of toxicity and the dead mice was not found. Conclusion: The findings of the present study can be concluded that EAFTR showed a hypoglicemic effect and did not show toxic symptom until dose 2000 mg/kg b.w.
Keywords: Blood glucose, Hypoglicemic Effect, acute Toxicity, Tofu Residue, Diabetes
|Kategori||:||Poster||No/Vol/Tahun||:||0 / 0 / 0|
|PTN/S||:||Universitas Pakuan||Program Studi||:||FARMASI|