Repository Universitas Pakuan

Detail Karya Ilmiah Dosen

Lusi Agus Setiani, Bina Lohita Sari

Judul : Activity of Antioxidant and Inhibitor α-Glucosidase Instant Granul Ethanol Tea Leaf Extract (Camellia sinensis) and Tea Benalu (Scurulla atropurpureea BL Dans)
Abstrak :

Tea leaves are plants that are widely spread especially in the area of West Java, while parasites are parasitic plants in tea trees that empirically have various properties such as antioxidants and anti diabetic. The α-glucosidase inhibitor is one of the therapeutic drugs for diabetic that works by inhibiting carbohydrate metabolism. Instant granule preparation is one form of dosage used by dissolving in water. This study aims to determine the antioxidant activity and inhibitors of instant granular α-glucosidase ethanolic extract of Tea and Tea Tea leaves. The extract was obtained from extraction with 60% ethanol solvent-assisted extraction (MAE) method. Research was done by making 3 formula (Formula 1, 2 and 3) with comparison of tea leaf extract, parasite, Polivinil pyrrolidone (PVP) and cyclodextrin ie 26,88%, 1,8%, 2%, 0% (Formula 1) 26.88%, 0%, 3%, 12% and 0% (Formula 2), 1.8%, 4%, 15% (Formula 3). Formula 2 is active as an antioxidant and α-glucosidase enzyme inhibitor with IC50 values of 68.21 and 56.76 ppm.

Tahun : 2018 Media Publikasi : Jurnal Nasional Blm Akreditasi
Kategori : Jurnal No/Vol/Tahun : 01 / 01 / 2018
ISSN/ISBN : 2615-3769
PTN/S : Universitas Pakuan Program Studi : FARMASI
Bibliography :

Ansel. 2005. Pengantar Bentuk Sediaan Farmasi Edisi Keempat. Terjemahan dari Introduction to Pharmaceutical Dosage Farms Oleh Farida Ibrahim. UI Press. Jakarta.

Christianty, M Fransiska., Holidah, D., Yasmin. 2016. In Vitro α-Glukosidase Inhibitory  Activity of Various Tea (Camelia sinensis L.) Extracts. In: Proceedings of ICMHS.

Fitrya. 2011. Flavonoid Kuersetin Dari Tumbuhan Benalu Teh (Scurulla atropurpurea BL. Dans). Jurnal Penelitian Sains. 14(4C). 14408 32-37.

Gu, C., Zhang, H., Putri, C. Y., and Ng, K., 2015, Evaluation of α-Amylase and α-Glucosidase Inhibitory Activity of Flavonoids, International Journal of Food and Nutritional Science, 2 (6), 1–6.

Mohan, C., Long, K. D., and Mutneja, M., 2013, An Introduction to Inhibitors and Their Biological Applications, EMD Millipore.

Lamson, Davis W, MS, ND, and Brignall, Matthew S. ND. 2000. Antioxidants and cancer III: Quercetin, Alternative Medicine Review.5(3)

Naghma, K. and Hasan M. (2008). Multitargeted therapy of cancer by green tea polyphenols. Cancer Letters. 269 : 269–280.

Ohashi  K, Winarno H, Mukai, M., Shibuya, H.. 2003. Preparation andcancer cell invasion inhibitory effects ofC16-alkynic fatty acids. Chemical and Pharmaceutical Bulletin.51 (4):  463-466.

Quan, P.T., Tong V. H., Nguyen H. H., Nguyen X.D., Truong N.T. 2006. Microwave-Assisted Extraction of Polyphenols from Fresh Tea Shoot.Jornal of Science & Technology Development. 9(8). 69-73

Sratton, I.M., Adler, A.I., Neil, H.A., Matthews, D.R., Manley, S.E., Cull,C.A, Hadden, D., Turner, R.C., and Holmann, R.R. (2000). Association of Glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. Br. Med. J. 321 (7258): 405–412.

Sugiwati, S., Setiasih, S., and Afifah, E., 2009, Antihiperglycemic Activity of The Mahkota Dewa [ Phaleria macrocarpa ( Scheff .) Boerl .] Leaf Extracts as an Alpha-Glucosidase Inhibitor, Makara, Kesehatan, 13 (2), 74–78.

Widowati, W. 2008. Potensi Antioksidan Sebagai Antidiabetes JKM Vol. 17, No.12. 1-11.

Winarsi,H.2007. Antioksidan Alami dan Radikal Bebas. Penerbit Kanisius. Yogyakarta.