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Detail Karya Ilmiah Dosen

Yuliana Kusumawati, Erni Rustiani, Almasyuhuri

Judul : PENGEMBANGAN TABLET EFERVESEN KOMBINASI BROKOLI DAN PEGAGAN DENGAN KOMBINASI ASAM DAN BASA

Abstrak :
Brocoli and pegagan is a plant that is easy to get and efficacious as antidemensia. The objective of this study was to formulate the plant into an effervescent tablet preparation and to determine the best formula with acid concentration variation. Dry extract of brocoli and pegagan is made by the method of escape then dried with vacuum dryer. The preparation is made by wet granulation method of 3 formula with weight of 4 gram per tablet. The granule test includes moisture content. Result of granule water content Ë‚5%. Granules are printed in special chambers and conditions and tested for quality. The result of uniform weight test of all formula meets the requirements of Pharmacopoeia Indonesia III; Hardness of tablets 12.06-12.52 kP; Friability of tablets 0.083-0.74%; Test of dissolution time of efervesen tablet Ë‚ 5 minutes. Preferred test results showed formula III with citric acid concentration: 1: 2 tartaric acid most preferred. ; Test result of asiatikosida content of pegagan extract is 0.08% and efervesen 0.005% tablet; Test results for vitamin C content of broccoli extract 13.859% and efevesen tablet 16.995%. The results of the physical quality test of effervescent tablets showed that the three formulas met the specified requirements. Stability test results for 8 weeks showed that the effervesen tablet of formula 3 met the requirements of physical quality during storage.

Keywords: Brocoli, Pegagan, Effervescent Tablets, Antidemensia

Tahun : 2017 Media Publikasi : Jurnal Nasional Terakreditasi B

Kategori : Jurnal No/Vol/Tahun : 2 / 4 / 2017

ISSN/ISBN : 2356-0398

PTN/S : UNPAK Program Studi : FARMASI

Bibliography :
Agoes, G. 2008. Pengembangan Sediaan Farmasi.

Penerbit   Institut   Teknologi   Bandung. Bandung. 303-315,

Anam, C., Kawiji., Setiawan, R., 2013, Kajian Karakteristik Fisik dan Sensori Serta Aktivitas Antioksidan dari Granul Effervescent Buah Beet Dengan Perbedaan

Metode Granulasi dan Kombinasi Sumber

Asam, Jurnal Teknosains Pangan, 2 (2),

23020733.

Aprilianto, Angga., Nugroho, Ardi., dan WFR, Iqbal.,

2010, Potensi Rumput Pegagan (Centella Asiatica linn) Sebagai Alternatif Suplemen Otak Pengganti Gingkgo biloba, PKM GT, Yogyakarta, Fakultas Farmasi UII.

Arisman, 2010, Buku Ajar Ilmu Gizi: Gizi Dalam

Daur Kehidupan, Jakarta, EGC.

Badan Pusat Statistik, 2012, Profil Kesehatan Ibu dan

Anak, Jakarta, Badan Pusat Statistik.

Banker, Peck, and Baley, 1980, Pharmaceutical Dosage Form: Tablet, Vol I, Edited by Leon Lachman and Herbert A. Lieberman, Marcel Dekker, Inc., New York, 71.

BPOM. 2014. Peraturan Kepala BPOM RI No.12 tahun 2014 tentang Persyaratan Mutu Obat Tradisional. Jakarta.

British National Formulary 57, 2009, Royal Pharmaceutical Society, Germany, BMJ Group and RPS Publishing.

Council of Europe. 1997. European Pharmacopoeia, Third Edition. Strasbourg. Hlm. 1753.

DepKes. 2008. Farmakope Herbal Indonesia EdisiI Indonesia. Departemen Kesehatan Republik Indonesia. Jakarta.

Direktorat Jenderal Pengawasan Obat dan Makanan

RI, 1979, Farmakope Indonesia, Edisi III., Jakarta, Departemen Kesehatan Republik Indonesia.

Fonner, D.E., Anderson, N.R., Banker, C.S., 1981.

Granulation and Tablet Characteristic in Lieberman, H.A., Lachman, L., (Eds). Pharmaceutical Dosage Form: Tablet, vol.2, Mercel Dekker Inc., New York, 226-231.

Mahan LK and EscottStump S., 2008, Weight Management, In : Mahan LK, EscottStump S.,        eds. Krause’s Food   & Nutrition Theraphy. 12th ed. St Saunders Elseviers.

Mohrle, R., 1980, Effervescent Tablet in Lieberman, H.A., Lachman, L,.(Eds)., Pharmaceutical Dosage Form : Tablet,1, 164, 1, New York, Marcel Dekker Inc.

Murdianto, W. & Syahrumsyah, H., 2012, Pengaruh

Natrium   Bikarbonat   Terhadap     Kadar

Vitamin C Total Padatan Terlarut dan Nilai Sensoris dari Sari Buah Nanas Berkarbonasi, Jurnal Teknologi Pertanian, 25.

Nihaya, A., 2016, Kajian Potensi Efek Antidemensia

Ekstrak Brokoli dan Pegagan Pada Mencit yang diinduksi Skopolamin, Skripsi, Bogor, Program Studi Farmasi FMIPA UNPAK.

Riviere, S. Birloquez-Aragon, I., Nourhashemi, F., & Vellas, B. 1998. Low Plasma Vitamin C in Alzheimer Patients Despite an Adequate Diet. International Journal Of Geriatric Psychiatry 13,.749-754.

Siregar, CJP. 2010. Teknologi Farmasi Sediaan Tablet

Dasar-Dasar Praktis. ECG. Jakarta.163. Smeltzer, C. Suzanne dan Bare G. Brenda., 2001,

Keperawatan Medikal Bedah, Edisi 8, Jakarta, EGC.

Sulaiman, T. N,. S. 2007. Teknologi dan Formulasi Sediaan Tablet. Pustaka Laboratorium Teknologi Farmasi Fakultas Farmasi UGM. Yogyakarta.

World    Alzheimer’s    Report,    2009,    London,

Alzheimer’s Disease International.

Yonet T I, Dhimas. 2010. Isolasi Asiaticosida dari Herba Pegagan dan Penetapan Kadarnya Menggunakan HPLC. Skripsi. Universitas Muhammadiyah. Surakarta.

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Detail Karya Ilmiah Dosen

Yuliana Kusumawati, Erni Rustiani, Almasyuhuri

Judul	:	PENGEMBANGAN TABLET EFERVESEN KOMBINASI BROKOLI DAN PEGAGAN DENGAN KOMBINASI ASAM DAN BASA
Abstrak	:	Brocoli and pegagan is a plant that is easy to get and efficacious as antidemensia. The objective of this study was to formulate the plant into an effervescent tablet preparation and to determine the best formula with acid concentration variation. Dry extract of brocoli and pegagan is made by the method of escape then dried with vacuum dryer. The preparation is made by wet granulation method of 3 formula with weight of 4 gram per tablet. The granule test includes moisture content. Result of granule water content Ë‚5%. Granules are printed in special chambers and conditions and tested for quality. The result of uniform weight test of all formula meets the requirements of Pharmacopoeia Indonesia III; Hardness of tablets 12.06-12.52 kP; Friability of tablets 0.083-0.74%; Test of dissolution time of efervesen tablet Ë‚ 5 minutes. Preferred test results showed formula III with citric acid concentration: 1: 2 tartaric acid most preferred. ; Test result of asiatikosida content of pegagan extract is 0.08% and efervesen 0.005% tablet; Test results for vitamin C content of broccoli extract 13.859% and efevesen tablet 16.995%. The results of the physical quality test of effervescent tablets showed that the three formulas met the specified requirements. Stability test results for 8 weeks showed that the effervesen tablet of formula 3 met the requirements of physical quality during storage. Keywords: Brocoli, Pegagan, Effervescent Tablets, Antidemensia
Tahun	:	2017	Media Publikasi	:	Jurnal Nasional Terakreditasi B
Kategori	:	Jurnal	No/Vol/Tahun	:	2 / 4 / 2017
ISSN/ISBN	:	2356-0398
PTN/S	:	UNPAK	Program Studi	:	FARMASI
Bibliography	:	Agoes, G. 2008. Pengembangan Sediaan Farmasi. Penerbit Institut Teknologi Bandung. Bandung. 303-315, Anam, C., Kawiji., Setiawan, R., 2013, Kajian Karakteristik Fisik dan Sensori Serta Aktivitas Antioksidan dari Granul Effervescent Buah Beet Dengan Perbedaan Metode Granulasi dan Kombinasi Sumber Asam, Jurnal Teknosains Pangan, 2 (2), 23020733. Aprilianto, Angga., Nugroho, Ardi., dan WFR, Iqbal., 2010, Potensi Rumput Pegagan (Centella Asiatica linn) Sebagai Alternatif Suplemen Otak Pengganti Gingkgo biloba, PKM GT, Yogyakarta, Fakultas Farmasi UII. Arisman, 2010, Buku Ajar Ilmu Gizi: Gizi Dalam Daur Kehidupan, Jakarta, EGC. Badan Pusat Statistik, 2012, Profil Kesehatan Ibu dan Anak, Jakarta, Badan Pusat Statistik. Banker, Peck, and Baley, 1980, Pharmaceutical Dosage Form: Tablet, Vol I, Edited by Leon Lachman and Herbert A. Lieberman, Marcel Dekker, Inc., New York, 71. BPOM. 2014. Peraturan Kepala BPOM RI No.12 tahun 2014 tentang Persyaratan Mutu Obat Tradisional. Jakarta. British National Formulary 57, 2009, Royal Pharmaceutical Society, Germany, BMJ Group and RPS Publishing. Council of Europe. 1997. European Pharmacopoeia, Third Edition. Strasbourg. Hlm. 1753. DepKes. 2008. Farmakope Herbal Indonesia EdisiI Indonesia. Departemen Kesehatan Republik Indonesia. Jakarta. Direktorat Jenderal Pengawasan Obat dan Makanan RI, 1979, Farmakope Indonesia, Edisi III., Jakarta, Departemen Kesehatan Republik Indonesia. Fonner, D.E., Anderson, N.R., Banker, C.S., 1981. Granulation and Tablet Characteristic in Lieberman, H.A., Lachman, L., (Eds). Pharmaceutical Dosage Form: Tablet, vol.2, Mercel Dekker Inc., New York, 226-231. Mahan LK and EscottStump S., 2008, Weight Management, In : Mahan LK, EscottStump S., eds. Krause’s Food & Nutrition Theraphy. 12th ed. St Saunders Elseviers. Mohrle, R., 1980, Effervescent Tablet in Lieberman, H.A., Lachman, L,.(Eds)., Pharmaceutical Dosage Form : Tablet,1, 164, 1, New York, Marcel Dekker Inc. Murdianto, W. & Syahrumsyah, H., 2012, Pengaruh Natrium Bikarbonat Terhadap Kadar Vitamin C Total Padatan Terlarut dan Nilai Sensoris dari Sari Buah Nanas Berkarbonasi, Jurnal Teknologi Pertanian, 25. Nihaya, A., 2016, Kajian Potensi Efek Antidemensia Ekstrak Brokoli dan Pegagan Pada Mencit yang diinduksi Skopolamin, Skripsi, Bogor, Program Studi Farmasi FMIPA UNPAK. Riviere, S. Birloquez-Aragon, I., Nourhashemi, F., & Vellas, B. 1998. Low Plasma Vitamin C in Alzheimer Patients Despite an Adequate Diet. International Journal Of Geriatric Psychiatry 13,.749-754. Siregar, CJP. 2010. Teknologi Farmasi Sediaan Tablet Dasar-Dasar Praktis. ECG. Jakarta.163. Smeltzer, C. Suzanne dan Bare G. Brenda., 2001, Keperawatan Medikal Bedah, Edisi 8, Jakarta, EGC. Sulaiman, T. N,. S. 2007. Teknologi dan Formulasi Sediaan Tablet. Pustaka Laboratorium Teknologi Farmasi Fakultas Farmasi UGM. Yogyakarta. World Alzheimer’s Report, 2009, London, Alzheimer’s Disease International. Yonet T I, Dhimas. 2010. Isolasi Asiaticosida dari Herba Pegagan dan Penetapan Kadarnya Menggunakan HPLC. Skripsi. Universitas Muhammadiyah. Surakarta.
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