Repository Universitas Pakuan

Detail Karya Ilmiah Dosen

Erni Rustiani, Min Rachminiwati, Lia Suryani

Judul : EFEKTIVITAS ANTIHIPERGLIKEMIA TABLET CAMPURAN EKSTRAK DAUN PEPAYA DAN DAUN SALAM PADA TIKUS Sprague dawley

Abstrak :
Plants which have a potential effect as antihyperglycemic are papaya leaf and bay leaf. Papaya leaf and

bay leaf have a bioactive flavonoid component, which was suggested to have reduction effect on blood glucose. The purpose of this research was to examine the effectiveness of papaya leaf and bay leaf extract, which have been formulated in tablet form to decrease blood glucose level on diabetic Sprague dawley rats induced by alloxan. Twenty male rats were divided into four groups, Each group consists of five rats, namely group I as a posit ive control (metformin 12.6 mg/200g BW), group II (oral tablet 1.282 mg/200g BW), group III (oral tablet 2.564 mg/200g BW) as extract treatment group, and group IV as negative control. The treatment was carried out for 28 days. The result of this research showed that tablet of papaya leaf and bay leaf extract can be used as antihyperglycemic with the most effective dose was 2.564 mg/200g BB (group III) and the treatment for twelve days.

Tahun : 2017 Media Publikasi : Jurnal Nasional Terakreditasi B

Kategori : Jurnal No/Vol/Tahun : 2 / 4 / 2017

ISSN/ISBN : 2356-0398

PTN/S : UNPAK Program Studi : FARMASI

Bibliography :
Auroma, O.I., Neergheen, V.S., Bahorum, T., Jen, L.S.

2006. Free radicals, antioxidants and diabetes: embryopathy, retinopathy, neuropathy, nephropathy,          and cardiovascular complications. Neuroembryol Aging 4: 117-137.

Ewenighi C., Uchechukwu D., Joel O., Linus O., Gladys O., Uchechukwu E. 2015. Estimation of Glucose Level and Body Weight in

Alloxan Induced Diabetic Rat Treated with Aqueous Extract of Garcinia Kola Seed. Ulutas Med Journal. 1(2):26-30

Hossain, M.K., Ahmed, A.D., Jihae H., Yingfu Y., Kyeongseok   K., Subbroto K.S., Gwang- Mo Y., Hye Y.S., Ssang-Goo C. 2016. Molecular Mechanisms of the Anti- Obesity and Anti-Diabetic Properties of Flavonoids.     International   Journal    of

Molecular Sciences. 17, 569.

Kaneto, H., Kajimoto, Y., Miyagawa, J., Matsuoka, T.

1999. Beneficial effects of antioxidants in diabetes: Possible protection of pancreatic β- Cells against glucose toxicity. Diabetes. 48:

2398-2406.

Montano, M.E, Molpeceres,V, MaurizJ.L, Garzo E, Cruz I.B, Gonzalez P, Barrio J.P. 2010. Effect of melatonin supplementation on food and water intake in streprozocin-diabetic and non- diabetic male Wistar rats. Nutr Hosp. 25:931-

938.

Musyrifah, S., Utaminingsih, B. dan Laili, F.N. 2012.

Pastiles Daun Salam (Eugenia Polyantha W). Yogyakarta: Universitas Gajah Mada.

Pournaghi, P, Rajab-Ali S., Shapour H., Azadeh F.

2012. An investigation on body weights, blood glucose levels and pituitary-gonadal axis hormones in diabetic and metformin- treated diabetic female rats Veterinary research forum. 3(2), 79-84.

Prabawati, M. 2015. Optimasi Dosis Granul Instan Ekstrak Daging Buah      Mahkota     Dewa Dan Daun Salam Sebagai Antihiperglikemik Pada Tikus Putih Jantan. Skripsi. FMIPA. Universitas Pakuan, Bogor.

Pupim L.B., Heimburger O., Qureshi A.R., Ikizler T.A., Stenvinkel P. 2005. Accelerated lean body mass loss in incident chronic dialysis patients with diabetes mellitus. Kidney Int.

68:2368–2374.

Rahmahuda, NK. 2014. Formulasi Sediaan Tablet Kombinasi Ekstrak Daun Pepaya Dan Daun Salam Dengan Variasi Konsentrasi Pengikat PVP K-30. Skripsi. FMIPA. Universitas Pakuan, Bogor.

Rojop I.E.J, Juan C, Jorge L.B, Pedro H.M.O, Andres

E.C.R, Carlos A.T.Z, Arturo R.H, Hidemi A.M, Teresa R.E, Deysi Y.B.O. 2012. Hypoglycemic effect of Carica papaya leaves in streptozotocin-induced diabetic rats. BMC Complementary and Alternative Medicine.

12:236.

Taufiqurrohman. 2015. Indonesian bay leaves as antidiabetic for type 2 diabetes mellitus. J Majority. 4 (3): 101-108.

Wild, S., Roglic, G., Green, A., Sicree, R., King, H.

2004. Global prevalence of diabetes. Diabetes Care 27: 1047–1053.

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Detail Karya Ilmiah Dosen

Erni Rustiani, Min Rachminiwati, Lia Suryani

Judul	:	EFEKTIVITAS ANTIHIPERGLIKEMIA TABLET CAMPURAN EKSTRAK DAUN PEPAYA DAN DAUN SALAM PADA TIKUS Sprague dawley
Abstrak	:	Plants which have a potential effect as antihyperglycemic are papaya leaf and bay leaf. Papaya leaf and bay leaf have a bioactive flavonoid component, which was suggested to have reduction effect on blood glucose. The purpose of this research was to examine the effectiveness of papaya leaf and bay leaf extract, which have been formulated in tablet form to decrease blood glucose level on diabetic Sprague dawley rats induced by alloxan. Twenty male rats were divided into four groups, Each group consists of five rats, namely group I as a posit ive control (metformin 12.6 mg/200g BW), group II (oral tablet 1.282 mg/200g BW), group III (oral tablet 2.564 mg/200g BW) as extract treatment group, and group IV as negative control. The treatment was carried out for 28 days. The result of this research showed that tablet of papaya leaf and bay leaf extract can be used as antihyperglycemic with the most effective dose was 2.564 mg/200g BB (group III) and the treatment for twelve days.
Tahun	:	2017	Media Publikasi	:	Jurnal Nasional Terakreditasi B
Kategori	:	Jurnal	No/Vol/Tahun	:	2 / 4 / 2017
ISSN/ISBN	:	2356-0398
PTN/S	:	UNPAK	Program Studi	:	FARMASI
Bibliography	:	Auroma, O.I., Neergheen, V.S., Bahorum, T., Jen, L.S. 2006. Free radicals, antioxidants and diabetes: embryopathy, retinopathy, neuropathy, nephropathy, and cardiovascular complications. Neuroembryol Aging 4: 117-137. Ewenighi C., Uchechukwu D., Joel O., Linus O., Gladys O., Uchechukwu E. 2015. Estimation of Glucose Level and Body Weight in Alloxan Induced Diabetic Rat Treated with Aqueous Extract of Garcinia Kola Seed. Ulutas Med Journal. 1(2):26-30 Hossain, M.K., Ahmed, A.D., Jihae H., Yingfu Y., Kyeongseok K., Subbroto K.S., Gwang- Mo Y., Hye Y.S., Ssang-Goo C. 2016. Molecular Mechanisms of the Anti- Obesity and Anti-Diabetic Properties of Flavonoids. International Journal of Molecular Sciences. 17, 569. Kaneto, H., Kajimoto, Y., Miyagawa, J., Matsuoka, T. 1999. Beneficial effects of antioxidants in diabetes: Possible protection of pancreatic β- Cells against glucose toxicity. Diabetes. 48: 2398-2406. Montano, M.E, Molpeceres,V, MaurizJ.L, Garzo E, Cruz I.B, Gonzalez P, Barrio J.P. 2010. Effect of melatonin supplementation on food and water intake in streprozocin-diabetic and non- diabetic male Wistar rats. Nutr Hosp. 25:931- 938. Musyrifah, S., Utaminingsih, B. dan Laili, F.N. 2012. Pastiles Daun Salam (Eugenia Polyantha W). Yogyakarta: Universitas Gajah Mada. Pournaghi, P, Rajab-Ali S., Shapour H., Azadeh F. 2012. An investigation on body weights, blood glucose levels and pituitary-gonadal axis hormones in diabetic and metformin- treated diabetic female rats Veterinary research forum. 3(2), 79-84. Prabawati, M. 2015. Optimasi Dosis Granul Instan Ekstrak Daging Buah Mahkota Dewa Dan Daun Salam Sebagai Antihiperglikemik Pada Tikus Putih Jantan. Skripsi. FMIPA. Universitas Pakuan, Bogor. Pupim L.B., Heimburger O., Qureshi A.R., Ikizler T.A., Stenvinkel P. 2005. Accelerated lean body mass loss in incident chronic dialysis patients with diabetes mellitus. Kidney Int. 68:2368–2374. Rahmahuda, NK. 2014. Formulasi Sediaan Tablet Kombinasi Ekstrak Daun Pepaya Dan Daun Salam Dengan Variasi Konsentrasi Pengikat PVP K-30. Skripsi. FMIPA. Universitas Pakuan, Bogor. Rojop I.E.J, Juan C, Jorge L.B, Pedro H.M.O, Andres E.C.R, Carlos A.T.Z, Arturo R.H, Hidemi A.M, Teresa R.E, Deysi Y.B.O. 2012. Hypoglycemic effect of Carica papaya leaves in streptozotocin-induced diabetic rats. BMC Complementary and Alternative Medicine. 12:236. Taufiqurrohman. 2015. Indonesian bay leaves as antidiabetic for type 2 diabetes mellitus. J Majority. 4 (3): 101-108. Wild, S., Roglic, G., Green, A., Sicree, R., King, H. 2004. Global prevalence of diabetes. Diabetes Care 27: 1047–1053.
URL	: